GDNF reduces oxidative stress in a 6-hydroxydopamine model of Parkinson's disease.

[olsen]

Neurosci Lett. 2006 Nov 22; [Epub ahead of print] Related Articles, Links


GDNF reduces oxidative stress in a 6-hydroxydopamine model of Parkinson's disease.

Smith MP, Cass WA.

Department of Anatomy and Neurobiology, MN-225 Chandler Medical Center, University of Kentucky College of Medicine, Lexington, Kentucky 40536-0298, USA.

Many current theories of Parkinson's disease (PD) suggest that oxidative stress is involved in the neurodegenerative process. Potential neuroprotective agents could protect neurons through inherent antioxidant properties or through the upregulation of the brain's antioxidant defenses. Glial cell line-derived neurotrophic factor (GDNF) has been shown to protect and restore dopamine neurons in experimental models of PD and to improve motor function in human patients. This study was designed to investigate GDNF's effect on oxidative stress in a model of PD. GDNF or vehicle was injected into the right striatum of male Fischer-344 rats. Three days later 6-OHDA or saline was injected into the same striatum. The striatum and substantia nigra from both sides of the brain were removed 24h after 6-OHDA or saline injection and analyzed for the oxidative stress markers protein carbonyls and 4-hydroxynonenal. Both markers were significantly reduced in GDNF+6-OHDA treated animals compared to vehicle+6-OHDA treated animals. In addition, in animals allowed to recover for 3.5-4 weeks after the 6-OHDA administration, the GDNF led to significant protection against loss of striatal and nigral tissue levels of dopamine. These results suggest that the protective effects of GDNF against 6-OHDA involve a reduction in oxidative stress.

PMID: 17125923 [PubMed - as supplied by publisher]

http://www.ncbi.nlm.nih.gov/entrez/q...&dopt=Abstract

[justrosey]

i have had parkinson's now for about 14 years. i am on sinemet, sinemet cr
and mirapex. as of late i have been losing my balance and falling. this seems to happen when i reach for something sidewides. i was wondering if there is any natural medicines out there for parkinson. so that i can investigate before telling my doctor i read about parkotab has any one tried it .

thanks,

justrosey

[justrosey]

i have found a natural med called parkotab has any one taken this med and if so how does it work.

also does any one know about the patch