New Research Challenges Concept of Vitamin D Deficiency

[venice*]

And this comes out just after I upped my intake by using D3 dots 1,000.
Should we minimize supplementation?
Venice

http://www.prweb.com/releases/2008/1/prweb639651.htm

New Research Challenges Concept of Vitamin D Deficiency
The vitamin D deficiency long interpreted as a cause of disease is more likely the result of the disease process and increasing intake of vitamin D often makes the disease worse.
Thousand Oaks, CA (PRWEB) January 21, 2008 -- Low blood levels of vitamin D have long been associated with disease, and the assumption has been made that vitamin D supplements may protect against disease. In the light of new knowledge that hundreds of genes are dependent on vitamin D, this assumption needs to be reconsidered.

In a report published in the current issue of the journal BioEssays(1), Trevor Marshall, Ph.D., professor at Australia's Murdoch University School of Biological Medicine and Biotechnology, explains how increased vitamin D intake affects much more than just nutrition or bone health. The paper explains how the Vitamin D Nuclear Receptor (VDR) acts in the repression or transcription of hundreds of genes, including genes associated with diseases ranging from cancers to multiple sclerosis….

"Our disease model has shown us why low levels of vitamin D are observed in association with major and chronic illness," Marshall added. "Vitamin D is a secosteroid hormone, and the body regulates the production of all it needs. In fact, the use of supplements can be harmful, because they suppress the immune system so that the body cannot fight disease and infection effectively."

Marshall's research has demonstrated how ingested vitamin D can actually block VDR activation, the opposite effect to that of Sunshine. Instead of a positive effect on gene expression, Marshall reported that his own work, as well as the work of others, shows that quite nominal doses of ingested vitamin D can suppress the proper operation of the immune system. It is a different metabolite, a secosteroid hormone called 1,25-dihydroxyvitamin D, which activates the VDR to regulate the expression of the genes. Under conditions that exist in infection or inflammation, the body automatically regulates its production of all the vitamin D metabolites, including 25-hydroxyvitamin D, the metabolite which is usually measured to indicate vitamin D status.

Vitamin D deficiency, long interpreted as a cause of disease, is more likely the result of the disease process, and increasing intake of vitamin D often makes the disease worse. "Dysregulation of vitamin D has been observed in many chronic diseases, including many thought to be autoimmune," said J.C. Waterhouse, Ph.D., lead author of a book chapter on vitamin D and chronic disease (2). "We have found that vitamin D supplementation, even at levels many consider desirable, interferes with recovery in these patients.

…We need to discard the notion that vitamin D affects a disease state in a simple way"

[MS Bites]

iNTERESTING HUH?

[Cat Dancer]

As my doctor said..and several folks here poo-pooed him..."all this talk about needing to add supplements, particularly in a normal American diet, is a bunch of hype."

[PattiLee]

Yup.

It figures.

This seems to be the norm. Every time a suppiment is said to help, "whatever,"

1. People all over the globe make somebody rich.
2. The official studies are done.
3. It turns out that the suppliment is harming us.

Gads.

PattiLee

[lady_express_44]

Cherie

[Braindead]

I have been trying to suppress my immune system for a long time by taking extra Vit D3 because have MS so I guess his statement that "nominal doses of ingested vitamin D can suppress the proper operation of the immune system" means that I am doing the right thing!!!

THINK ABOUT IT FOLKS!!!! THINK!!! THINK!!!

Braindead

P.S I may not be deficient in Vit D but more Vit D for me seems to be better for me and most folks with MS. In the world of MS folks "things" are different.

[BBS1951]

Oh brother.

So, Do I carve out the D from the calcium tablets? Or just buy calcium tabs without D? OR wait for the next resesarch article that shows why this one's conclusion is incorrect.

Oh Brother.

[lady_express_44]

Originally Posted by Braindead

I guess his statement that "nominal doses of ingested vitamin D can suppress the proper operation of the immune system" means that I am doing the right thing!!!

THINK ABOUT IT FOLKS!!!! THINK!!! THINK!!!

I'm thinking that Trevor Marshall, Ph.D., Professor at Australia's Murdoch University School of Biological Medicine and Biotechnology . . . would be well versed on the immune system, and is challenging common theories.

http://members.aol.com/SynergyHN/MPNews10-1

Cherie

[blossom4th]

I guess the motto "all things in moderation" is good,huh?!

[mmcc53]

Actually what he is saying SUPPORTS what the nurse study found. Our immune systems are OVER active - they need to be suppressed. His article is directed at disease in general, not auto-immune disease in particular.

The nurse study which is based on an enormous number of people over many years found that those taking a multi-vitamin that contains Vitamin D had a substantially lower incidence of MS.

That study absolutely suggests that taking a multi-vitamin with vitamin D can be helpful and even preventative. This guys research is saying that vitamin supplementation can suppress the immune system - a possible REASON why the nurse study showed what it did.

The nurse study did NOT advocate enormous vitamin D doses.