flatfish
01-24-2007, 01:57 PM
----- Original Message -----
From: Terry S. Singeltary Sr.
To: jschorg@iga.state.in.us
Cc: Bob Segall
Sent: Wednesday, January 24, 2007 11:54 AM
Subject: re-- House Bill 1502 (making cjd and all human TSE reportable OF ALL AGES)
Greetings Honorable Rep. David Orentlicher,
IN regards to House Bill 1502.............
THANK YOU SIR !!!
House Bill 1502
2007 Regular Session
Latest Information
DIGEST OF INTRODUCED BILL
Public health issues. Requires the state department of health to include Creutzfeldt-Jakob disease as a communicable disease, and requires specified persons to report a diagnosis of the disease. Requires a county coroner to perform an autopsy on an individual with a suspected diagnosis of Creutzfeldt-Jakob disease. Provides that the consent of a patient or the patient's representative to HIV screening may be either oral or in writing. Provides that an employee is entitled to an isolation or quarantine employment leave under certain circumstances...SNIP
http://www.in.gov/apps/lsa/session/billwatch/billinfo?year=2007&session=1&request=getBill&docno=1502
Creutzfeldt-Jakob Disease (CJD)
A degenerative and fatal nervous system disorder. Affected individuals can remain asymptomatic for decades after infection and then progress rapidly to dementia, severe loss of coordination and death. We are told by the Blood establishment that the risk of CJD being transmitted through Blood products is 'theoretical.' The infectious agent has (yes, has) been found in Blood products.
Today CJD is, in our opinion, under-researched, under-investigated and extremely under-reported. CJD cases around the world by geographical area show that CJD is more common than generally thought. This disease is feared and avoided by many medical professionals when diagnosed in its advanced stages. It resembles in many ways the infamous Mad Cow Disease or Bovine Spongiform Encephalopathy (BSE). There is also concern about Chronic Wasting Disease (New Mad Cow Disease). As in Mad Cow Disease, scientists believe abnormal brain proteins that have undergone a peculiar shape change can cause other brain proteins to do the same causing CJD. Variants are nCJD, vCJD and nvCJD.
Transmission of CJD has been proven from human to human by the transplantation of dura mater, the injection of pituitary-derived human growth hormone, and more rarely by the reuse of EEG electrodes and corneal transplantation. Currently, there is no test for the disease, however, all Blood banking organizations in Europe and US, prohibit Blood donation by individuals who have symptoms or a family history of symptoms. Blood donors are carefully questioned about family history of CJD and surgeries that involved transplanted dura mater. If they answer affirmatively to any of these questions, they are permanently deferred as a donor. There is no possibility of contracting CJD by making a normal Blood donation.
http://bloodindex.org/cjd.php
4th CASE VCJD VIA BLOOD TRANSFUSION, BSE, BASE, AND SPORADIC CJD
By Terry S Singeltary
http://bloodindex.org/news_zone.php
4th CASE VCJD VIA BLOOD TRANSFUSION, BSE, BASE, AND SPORADIC CJD
By Terry S Singeltary PART I
http://bloodindex.org/view_news_zone.php?id=206
4th CASE VCJD VIA BLOOD TRANSFUSION, BSE, BASE, AND SPORADIC CJD
By Terry S Singeltary PART II
http://bloodindex.org/view_news_zone.php?id=207
18 January 2007 - Draft minutes of the SEAC 95 meeting (426 KB) held on 7
December 2006 are now available.
snip...
4. Members had received information about the notification by the Health
Protection Agency (HPA) of recipients of four batches of plasma products
that had been produced from blood donated by individuals that had later
developed variant Creutzfeldt Jakob Disease (vCJD). THESE batches HAD NOT
been included in a similar notification exercise in 2004, as the fate of
these products COULD NOT BE TRACED at that time. The fourteenth annual
report of the National CJD Surveillance Unit had been published. The
European Food Safety Authority (EFSA) had issued a consultation on a revised
methodology for geographical bovine spongiform encephalopathy (BSE) risk
assessment. Members could submit individual responses. Submission of a SEAC
response was under consideration.
snip...
ITEM 9 - ANY OTHER BUSINESS
snip...
***$$$***
64. A member noted that at the recent Neuroprion meeting, a study was
presented showing that in transgenic mice BSE passaged in sheep may be more
virulent and infectious to a wider range of species than bovine derived BSE.
Other work presented suggested that BSE and bovine amyloidotic spongiform
encephalopathy (BASE) MAY BE RELATED. A mutation had been identified in the
prion protein gene in an AMERICAN BASE CASE THAT WAS SIMILAR IN NATURE TO A
MUTATION FOUND IN CASES OF SPORADIC CJD. A study also demonstrated that in a
mouse model it was possible to alleviate the pathological changes of prion
disease by suppressing expression of the prion protein gene after infection.
http://www.seac.gov.uk/minutes/95.pdf
3:00 Afternoon Refreshment Break, Poster and Exhibit Viewing in the Exhibit
Hall
3:30 Transmission of the Italian Atypical BSE (BASE) in Humanized Mouse
Models Qingzhong Kong, Ph.D., Assistant Professor, Pathology, Case Western Reserve
University
Bovine Amyloid Spongiform Encephalopathy (BASE) is an atypical BSE strain
discovered recently in Italy, and similar or different atypical BSE cases
were also reported in other countries. The infectivity and phenotypes of
these atypical BSE strains in humans are unknown. In collaboration with
Pierluigi Gambetti, as well as Maria Caramelli and her co-workers, we have
inoculated transgenic mice expressing human prion protein with brain
homogenates from BASE or BSE infected cattle. Our data shows that about half
of the BASE-inoculated mice became infected with an average incubation time
of about 19 months; in contrast, none of the BSE-inoculated mice appear to
be infected after more than 2 years. ***These results indicate that BASE is
transmissible to humans and suggest that BASE is more virulent than
classical BSE in humans.
6:30 Close of Day One
http://www.healthtech.com/2007/tse/day1.asp
SEE STEADY INCREASE IN SPORADIC CJD IN THE USA FROM
1997 TO 2006. SPORADIC CJD CASES TRIPLED, with phenotype
of 'UNKNOWN' strain growing. ...
http://www.cjdsurveillance.com/resources-casereport.html
There is a growing number of human CJD cases, and they were presented last
week in San Francisco by Luigi Gambatti(?) from his CJD surveillance
collection.
He estimates that it may be up to 14 or 15 persons which display selectively
SPRPSC and practically no detected RPRPSC proteins.
http://www.fda.gov/ohrms/dockets/ac/06/transcripts/1006-4240t1.htm
http://www.fda.gov/ohrms/dockets/ac/06/transcripts/2006-4240t1.pdf
JOURNAL OF NEUROLOGY
MARCH 26, 2003
RE-Monitoring the occurrence of emerging forms of Creutzfeldt-Jakob
disease in the United States
Email Terry S. Singeltary:
flounder@wt.net
I lost my mother to hvCJD (Heidenhain Variant CJD). I would like to
comment on the CDC's attempts to monitor the occurrence of emerging
forms of CJD. Asante, Collinge et al [1] have reported that BSE
transmission to the 129-methionine genotype can lead to an alternate
phenotype that is indistinguishable from type 2 PrPSc, the commonest
sporadic CJD. However, CJD and all human TSEs are not reportable
nationally. CJD and all human TSEs must be made reportable in every
state and internationally. I hope that the CDC does not continue to
expect us to still believe that the 85%+ of all CJD cases which are
sporadic are all spontaneous, without route/source. We have many TSEs in
the USA in both animal and man. CWD in deer/elk is spreading rapidly and
CWD does transmit to mink, ferret, cattle, and squirrel monkey by
intracerebral inoculation. With the known incubation periods in other
TSEs, oral transmission studies of CWD may take much longer. Every
victim/family of CJD/TSEs should be asked about route and source of this
agent. To prolong this will only spread the agent and needlessly expose
others. In light of the findings of Asante and Collinge et al, there
should be drastic measures to safeguard the medical and surgical arena
from sporadic CJDs and all human TSEs. I only ponder how many sporadic
CJDs in the USA are type 2 PrPSc?
http://www.neurology.org/cgi/eletters/60/2/176#535
Diagnosis and Reporting of Creutzfeldt-Jakob Disease
Singeltary, Sr et al. JAMA.2001; 285: 733-734.
http://jama.ama-assn.org/
BRITISH MEDICAL JOURNAL
BMJ
http://www.bmj.com/cgi/eletters/319/7220/1312/b#EL2
BMJ
http://www.bmj.com/cgi/eletters/320/7226/8/b#EL1
[Docket No. 03-025IFA] FSIS Prohibition of the Use of Specified Risk
Materials for Human Food and Requirement for the Disposition of
Non-Ambulatory Disabled Cattle
http://www.fsis.usda.gov/OPPDE/Comments/03-025IFA/03-025IFA-2.pdf
[Docket No. FSIS-2006-0011] FSIS Harvard Risk Assessment of Bovine
Spongiform Encephalopathy (BSE)
http://www.fsis.usda.gov/OPPDE/Comments/2006-0011/2006-0011-1.pdf
THE SEVEN SCIENTIST REPORT ***
http://www.fda.gov/ohrms/dockets/dockets/02n0273/02n-0273-EC244-Attach-1.pdf
PAUL BROWN M.D.
http://www.fda.gov/ohrms/dockets/dockets/02n0273/02n-0273-c000490-vol40.pdf
Terry S. Singeltary Sr.
P.O. Box 42
Bacliff, Texas USA 77518
From: Terry S. Singeltary Sr.
To: jschorg@iga.state.in.us
Cc: Bob Segall
Sent: Wednesday, January 24, 2007 11:54 AM
Subject: re-- House Bill 1502 (making cjd and all human TSE reportable OF ALL AGES)
Greetings Honorable Rep. David Orentlicher,
IN regards to House Bill 1502.............
THANK YOU SIR !!!
House Bill 1502
2007 Regular Session
Latest Information
DIGEST OF INTRODUCED BILL
Public health issues. Requires the state department of health to include Creutzfeldt-Jakob disease as a communicable disease, and requires specified persons to report a diagnosis of the disease. Requires a county coroner to perform an autopsy on an individual with a suspected diagnosis of Creutzfeldt-Jakob disease. Provides that the consent of a patient or the patient's representative to HIV screening may be either oral or in writing. Provides that an employee is entitled to an isolation or quarantine employment leave under certain circumstances...SNIP
http://www.in.gov/apps/lsa/session/billwatch/billinfo?year=2007&session=1&request=getBill&docno=1502
Creutzfeldt-Jakob Disease (CJD)
A degenerative and fatal nervous system disorder. Affected individuals can remain asymptomatic for decades after infection and then progress rapidly to dementia, severe loss of coordination and death. We are told by the Blood establishment that the risk of CJD being transmitted through Blood products is 'theoretical.' The infectious agent has (yes, has) been found in Blood products.
Today CJD is, in our opinion, under-researched, under-investigated and extremely under-reported. CJD cases around the world by geographical area show that CJD is more common than generally thought. This disease is feared and avoided by many medical professionals when diagnosed in its advanced stages. It resembles in many ways the infamous Mad Cow Disease or Bovine Spongiform Encephalopathy (BSE). There is also concern about Chronic Wasting Disease (New Mad Cow Disease). As in Mad Cow Disease, scientists believe abnormal brain proteins that have undergone a peculiar shape change can cause other brain proteins to do the same causing CJD. Variants are nCJD, vCJD and nvCJD.
Transmission of CJD has been proven from human to human by the transplantation of dura mater, the injection of pituitary-derived human growth hormone, and more rarely by the reuse of EEG electrodes and corneal transplantation. Currently, there is no test for the disease, however, all Blood banking organizations in Europe and US, prohibit Blood donation by individuals who have symptoms or a family history of symptoms. Blood donors are carefully questioned about family history of CJD and surgeries that involved transplanted dura mater. If they answer affirmatively to any of these questions, they are permanently deferred as a donor. There is no possibility of contracting CJD by making a normal Blood donation.
http://bloodindex.org/cjd.php
4th CASE VCJD VIA BLOOD TRANSFUSION, BSE, BASE, AND SPORADIC CJD
By Terry S Singeltary
http://bloodindex.org/news_zone.php
4th CASE VCJD VIA BLOOD TRANSFUSION, BSE, BASE, AND SPORADIC CJD
By Terry S Singeltary PART I
http://bloodindex.org/view_news_zone.php?id=206
4th CASE VCJD VIA BLOOD TRANSFUSION, BSE, BASE, AND SPORADIC CJD
By Terry S Singeltary PART II
http://bloodindex.org/view_news_zone.php?id=207
18 January 2007 - Draft minutes of the SEAC 95 meeting (426 KB) held on 7
December 2006 are now available.
snip...
4. Members had received information about the notification by the Health
Protection Agency (HPA) of recipients of four batches of plasma products
that had been produced from blood donated by individuals that had later
developed variant Creutzfeldt Jakob Disease (vCJD). THESE batches HAD NOT
been included in a similar notification exercise in 2004, as the fate of
these products COULD NOT BE TRACED at that time. The fourteenth annual
report of the National CJD Surveillance Unit had been published. The
European Food Safety Authority (EFSA) had issued a consultation on a revised
methodology for geographical bovine spongiform encephalopathy (BSE) risk
assessment. Members could submit individual responses. Submission of a SEAC
response was under consideration.
snip...
ITEM 9 - ANY OTHER BUSINESS
snip...
***$$$***
64. A member noted that at the recent Neuroprion meeting, a study was
presented showing that in transgenic mice BSE passaged in sheep may be more
virulent and infectious to a wider range of species than bovine derived BSE.
Other work presented suggested that BSE and bovine amyloidotic spongiform
encephalopathy (BASE) MAY BE RELATED. A mutation had been identified in the
prion protein gene in an AMERICAN BASE CASE THAT WAS SIMILAR IN NATURE TO A
MUTATION FOUND IN CASES OF SPORADIC CJD. A study also demonstrated that in a
mouse model it was possible to alleviate the pathological changes of prion
disease by suppressing expression of the prion protein gene after infection.
http://www.seac.gov.uk/minutes/95.pdf
3:00 Afternoon Refreshment Break, Poster and Exhibit Viewing in the Exhibit
Hall
3:30 Transmission of the Italian Atypical BSE (BASE) in Humanized Mouse
Models Qingzhong Kong, Ph.D., Assistant Professor, Pathology, Case Western Reserve
University
Bovine Amyloid Spongiform Encephalopathy (BASE) is an atypical BSE strain
discovered recently in Italy, and similar or different atypical BSE cases
were also reported in other countries. The infectivity and phenotypes of
these atypical BSE strains in humans are unknown. In collaboration with
Pierluigi Gambetti, as well as Maria Caramelli and her co-workers, we have
inoculated transgenic mice expressing human prion protein with brain
homogenates from BASE or BSE infected cattle. Our data shows that about half
of the BASE-inoculated mice became infected with an average incubation time
of about 19 months; in contrast, none of the BSE-inoculated mice appear to
be infected after more than 2 years. ***These results indicate that BASE is
transmissible to humans and suggest that BASE is more virulent than
classical BSE in humans.
6:30 Close of Day One
http://www.healthtech.com/2007/tse/day1.asp
SEE STEADY INCREASE IN SPORADIC CJD IN THE USA FROM
1997 TO 2006. SPORADIC CJD CASES TRIPLED, with phenotype
of 'UNKNOWN' strain growing. ...
http://www.cjdsurveillance.com/resources-casereport.html
There is a growing number of human CJD cases, and they were presented last
week in San Francisco by Luigi Gambatti(?) from his CJD surveillance
collection.
He estimates that it may be up to 14 or 15 persons which display selectively
SPRPSC and practically no detected RPRPSC proteins.
http://www.fda.gov/ohrms/dockets/ac/06/transcripts/1006-4240t1.htm
http://www.fda.gov/ohrms/dockets/ac/06/transcripts/2006-4240t1.pdf
JOURNAL OF NEUROLOGY
MARCH 26, 2003
RE-Monitoring the occurrence of emerging forms of Creutzfeldt-Jakob
disease in the United States
Email Terry S. Singeltary:
flounder@wt.net
I lost my mother to hvCJD (Heidenhain Variant CJD). I would like to
comment on the CDC's attempts to monitor the occurrence of emerging
forms of CJD. Asante, Collinge et al [1] have reported that BSE
transmission to the 129-methionine genotype can lead to an alternate
phenotype that is indistinguishable from type 2 PrPSc, the commonest
sporadic CJD. However, CJD and all human TSEs are not reportable
nationally. CJD and all human TSEs must be made reportable in every
state and internationally. I hope that the CDC does not continue to
expect us to still believe that the 85%+ of all CJD cases which are
sporadic are all spontaneous, without route/source. We have many TSEs in
the USA in both animal and man. CWD in deer/elk is spreading rapidly and
CWD does transmit to mink, ferret, cattle, and squirrel monkey by
intracerebral inoculation. With the known incubation periods in other
TSEs, oral transmission studies of CWD may take much longer. Every
victim/family of CJD/TSEs should be asked about route and source of this
agent. To prolong this will only spread the agent and needlessly expose
others. In light of the findings of Asante and Collinge et al, there
should be drastic measures to safeguard the medical and surgical arena
from sporadic CJDs and all human TSEs. I only ponder how many sporadic
CJDs in the USA are type 2 PrPSc?
http://www.neurology.org/cgi/eletters/60/2/176#535
Diagnosis and Reporting of Creutzfeldt-Jakob Disease
Singeltary, Sr et al. JAMA.2001; 285: 733-734.
http://jama.ama-assn.org/
BRITISH MEDICAL JOURNAL
BMJ
http://www.bmj.com/cgi/eletters/319/7220/1312/b#EL2
BMJ
http://www.bmj.com/cgi/eletters/320/7226/8/b#EL1
[Docket No. 03-025IFA] FSIS Prohibition of the Use of Specified Risk
Materials for Human Food and Requirement for the Disposition of
Non-Ambulatory Disabled Cattle
http://www.fsis.usda.gov/OPPDE/Comments/03-025IFA/03-025IFA-2.pdf
[Docket No. FSIS-2006-0011] FSIS Harvard Risk Assessment of Bovine
Spongiform Encephalopathy (BSE)
http://www.fsis.usda.gov/OPPDE/Comments/2006-0011/2006-0011-1.pdf
THE SEVEN SCIENTIST REPORT ***
http://www.fda.gov/ohrms/dockets/dockets/02n0273/02n-0273-EC244-Attach-1.pdf
PAUL BROWN M.D.
http://www.fda.gov/ohrms/dockets/dockets/02n0273/02n-0273-c000490-vol40.pdf
Terry S. Singeltary Sr.
P.O. Box 42
Bacliff, Texas USA 77518