thomasdevos
10-05-2009, 10:57 PM
Prognosis of prostate cancer at its best!
May University of Michigan researchers just taken a step closer to a simple urine test that tells how aggressive a prostate cancer may be indicating that the prognosis of prostate cancer has been further improved.
One of the challenges of this type of cancer is indicative of the aggressive form of the disease more relaxed version. Not being able to tell them apart prompts treatment (not to mention the side effects and stress) that may not even be necessary. Using a powerful new science known as metabolomics, the team found an amino acid derivative obscure, known as sarcosine May that said if a patient has an aggressive form or benign disease.
The pioneering work shows the value of metabolomics, a new technology that uses computer driven robots, which can quickly identify all chemicals that accumulate in body cells. This accumulation consists of metabolites ? products of finite number of biochemical reactions that occur in body cells. Sarcosine is one of them.
What the team did was to compare the metabolites from normal cells to those of both aggressive and nonaggressive cell cancer of the prostate, find ten (of 1,126) metabolites that distinguish normal cells from cancer cells. What is even more intriguing, the metabolites tend to increase or decrease as the cells of the prostate cancer becomes more aggressive. Free cancer cells were no signs of sarcosine.
But that's not all ?
When cells of benign prostate cancer are exposed to sarcosine they become nasty, aggressive and invasive. When the aggressive cancer cells are deprived of sarcosine, they become much less aggressive. The work should be confirmed and validated by larger studies, these results are surprising applications for diagnosis and treatment of prostate cancer dangerous.
The leader of the study, Dr. Arul Chinnaiyan, MD, PhD, professor of pathology and urology at the University of Michigan, Ann Arbor, said: "We have tantalizing evidence that this pathway of sarcosine may be involved in the pathogenesis of prostate cancer. The study found that levels of sarcosine were high in 79% of samples of aggressive cancer of the prostate, 42% of samples of early stage cancer and no cancer free samples.
Based on the work, published in the February issue of Nature, the sarcosine was better at detecting cancers developed the test in use today, the traditional Prostate Specific Antigen, PSA, test. The study also found that sarcosine may be involved in the same way inked an invasive cancer to know the content of a potential treatment of cancer.
However, more work is needed. Samples must be collected from a large number of men at all stages of the disease, before markers can be specifically developed. Estimates from the American Cancer Society have over 186,000 American men diagnosed with prostate cancer in 2008, the disease will claim more than 28,000 lives. Four of the five cases are diagnosed in men over 65 years, and very rarely in men before age 50. Nobody knows what causes it, but experts agree that what you eat (large amounts of fat from red meat) probably increases the risk.
Another theory suggests that fats trigger hormones like testosterone that the rate of growth of prostate cancer or push sleeper cells in action.
Today, there are a variety of different treatments for this disease of older men ? new techniques and surgeries on the up and coming drugs are so many options available to help manage the prognosis of cancer prostate. Find the right doctor and treatment is essential because if you wait more work to do.
Reference Site:
prostate cancer treatment (http://prostate-cancer-treatment-cure.com)
prostatecancerfoundation (http://www.prostatecancerfoundation.org)
en.wikipedia.org (http://en.wikipedia.org/wiki/Prostate_cancer)
www.cancer.gov (http://www.cancer.gov/cancertopics/types/prostate)
neworiental (http://www.neworiental.org/publish/portal0/tab1127/info377702.htm)
May University of Michigan researchers just taken a step closer to a simple urine test that tells how aggressive a prostate cancer may be indicating that the prognosis of prostate cancer has been further improved.
One of the challenges of this type of cancer is indicative of the aggressive form of the disease more relaxed version. Not being able to tell them apart prompts treatment (not to mention the side effects and stress) that may not even be necessary. Using a powerful new science known as metabolomics, the team found an amino acid derivative obscure, known as sarcosine May that said if a patient has an aggressive form or benign disease.
The pioneering work shows the value of metabolomics, a new technology that uses computer driven robots, which can quickly identify all chemicals that accumulate in body cells. This accumulation consists of metabolites ? products of finite number of biochemical reactions that occur in body cells. Sarcosine is one of them.
What the team did was to compare the metabolites from normal cells to those of both aggressive and nonaggressive cell cancer of the prostate, find ten (of 1,126) metabolites that distinguish normal cells from cancer cells. What is even more intriguing, the metabolites tend to increase or decrease as the cells of the prostate cancer becomes more aggressive. Free cancer cells were no signs of sarcosine.
But that's not all ?
When cells of benign prostate cancer are exposed to sarcosine they become nasty, aggressive and invasive. When the aggressive cancer cells are deprived of sarcosine, they become much less aggressive. The work should be confirmed and validated by larger studies, these results are surprising applications for diagnosis and treatment of prostate cancer dangerous.
The leader of the study, Dr. Arul Chinnaiyan, MD, PhD, professor of pathology and urology at the University of Michigan, Ann Arbor, said: "We have tantalizing evidence that this pathway of sarcosine may be involved in the pathogenesis of prostate cancer. The study found that levels of sarcosine were high in 79% of samples of aggressive cancer of the prostate, 42% of samples of early stage cancer and no cancer free samples.
Based on the work, published in the February issue of Nature, the sarcosine was better at detecting cancers developed the test in use today, the traditional Prostate Specific Antigen, PSA, test. The study also found that sarcosine may be involved in the same way inked an invasive cancer to know the content of a potential treatment of cancer.
However, more work is needed. Samples must be collected from a large number of men at all stages of the disease, before markers can be specifically developed. Estimates from the American Cancer Society have over 186,000 American men diagnosed with prostate cancer in 2008, the disease will claim more than 28,000 lives. Four of the five cases are diagnosed in men over 65 years, and very rarely in men before age 50. Nobody knows what causes it, but experts agree that what you eat (large amounts of fat from red meat) probably increases the risk.
Another theory suggests that fats trigger hormones like testosterone that the rate of growth of prostate cancer or push sleeper cells in action.
Today, there are a variety of different treatments for this disease of older men ? new techniques and surgeries on the up and coming drugs are so many options available to help manage the prognosis of cancer prostate. Find the right doctor and treatment is essential because if you wait more work to do.
Reference Site:
prostate cancer treatment (http://prostate-cancer-treatment-cure.com)
prostatecancerfoundation (http://www.prostatecancerfoundation.org)
en.wikipedia.org (http://en.wikipedia.org/wiki/Prostate_cancer)
www.cancer.gov (http://www.cancer.gov/cancertopics/types/prostate)
neworiental (http://www.neworiental.org/publish/portal0/tab1127/info377702.htm)