flatfish
12-05-2006, 10:13 PM
CJD (NEW VAR.) UPDATE 2006 (12)
*******************************
A ProMED-mail post
<http://www.promedmail.org>
ProMED-mail is a program of the
International Society for Infectious Diseases
<http://www.isid.org>
[The definition of the designations deaths, definite cases, probable
vCJD cases, and the case definitions can be found by accessing the
Department of Health website, or by reference to a previous
ProMED-mail post in this thread (for example, CJD (new var.) - UK:
update March 2002 20020305.3693).
Data on vCJD cases from other parts of the world are now included in
these updates whenever available.
Also, data on other forms of CJD (sporadic, iatrogenic, familial and
GSS) are now included when they have some relevance to the incidence
and etiology of vCJD. - Mod.CP]
In this update:
[1] UK: Department of Health monthly vCJD and CJD statistics, Mon 4 Dec 2006
[2] EUROCJD data as of 31 October 2006
[3] National (US) Prion Disease Pathology Surveillance Center Data: 8 Nov 2006
[4] The Netherlands: 2nd vCJD death
[5] USA: 3rd vCJD case (ex Saudi Arabia)
******
[1] UK: vCJD and CJD statistics
Date: Mon 4 Dec 2006
From: ProMED-mail <promed@promedmail.org>
Source: UK Department of Health, Monthly Creutzfeldt-Jakob Disease
Statistics, Mon 4 Dec 2006 [edited]
<http://www.gnn.gov.uk/environment/fullDetail.asp?ReleaseID=247744&NewsAreaID=2&NavigatedFromDepartment=False>
The Department of Health is today [Mon 4 Dec 2006] issuing the latest
information about the numbers of known cases of Creutzfeldt-Jakob
disease. This includes cases of variant Creutzfeldt-Jakob disease
[abbreviated in ProMED-mail as CJD (new var.) or vCJD], the form of
the disease thought to be linked to BSE (bovine spongiform encephalopathy).
Definite and probable CJD cases in the UK, as at Fri 1 Dec 2006
----------------------------------------------------------------
Summary of vCJD cases - deaths
------------------------------
Deaths from definite vCJD (confirmed): 112
Deaths from probable vCJD (without neuropathological confirmation): 46
Deaths from probable vCJD (neuropathological confirmation pending): 0
Number of deaths from definite or probable vCJD (as above): 158
Summary of vCJD cases - alive
-----------------------------
Number of probable vCJD cases still alive: 6
Total
-----
Number of definite or probable vCJD (dead and alive): 164
(The next table will be published on Mon 8 Jan 2007).
Since the previous monthly statistics were released on Mon 6 Nov
2006, the total number of deaths from definite vCJD remains unchanged
and stands at 158. The overall total number of definite or probable
vCJD cases (dead and alive) remains unchanged at 164.
These data are consistent with the view that the vCJD outbreak in the
UK is in decline. The peak number of deaths was 28 in the year 2000,
followed by 20 in 2001, 17 in 2002, 18 in 2003, 9 in 2004, and 5 in
2005. The number of deaths due to definite or probable vCJD in the UK
during the first 11 months of 2006 remains at 5.
Totals for all types of CJD cases in the UK in 2005 and 2006
----------------------------------------------------
As of Fri 1 Dec 2006, in the UK in the year 2005, there were 123
referrals of suspected CJD, and there were 65 deaths from sporadic
CJD, 7 from familial CJD, 3 from iatrogenic CJD, 6 GSS
(Gerstmann-Straussler-Scheinker) syndrome cases, and 5 deaths from vCJD.
The corresponding figures so far for the 1st 11 months of 2006 are:
98 referrals, 53 deaths from sporadic CJD, 5 from vCJD, 5 from
familial CJD, 3 from GSS and one from iatrogenic CJD.
During the period from 1995, when vCJD was first diagnosed, up to the
present there have been 953 deaths from all forms of CJD including
the 158 deaths attributable to definite or probable vCJD.
[These data are accessible via
<http://www.gnn.gov.uk/environment/fullDetail.asp?ReleaseID=247744&NewsAreaID=2&NavigatedFromDepartment=False>]
--
ProMED-mail
<promed@promedmail.org>
******
[2] EU - EUROCJD Data
Date: Tue 31 Oct 2006
From: ProMED-mail <promed@promedmail.org>
Source: EUROCJD 31 Oct 2006 [edited]
<http://www.eurocjd.ed.ac.uk/vcjdworldeuro.htm>
The European And Allied Countries Collaborative Study Group of CJD (EUCJD)
----------------------------------------------------
This web-site includes information from 2 projects funded by the
European Commission. The EUROCJD project started in 1993 and compares
data from national registries in Australia, Austria, Canada, France,
Germany, Italy, the Netherlands, Slovakia, Spain, Switzerland and the
UK. The NEUROCJD project started in 1998 after the European Union
Council recommended that epidemiological surveillance of CJD should
be extended to all member states. The member states involved in this
project are Belgium, Denmark, Finland, Greece, Iceland, Ireland,
Israel, Norway and Portugal. Both projects are coordinated from the
U.K. National CJD Surveillance Unit based in Edinburgh.
Current data as at November 2006*
---------------------------------
Country / Total No. of Primary cases (No. alive) / Cumulative
residence in UK (>6 months) / Secondary transmission by blood transfusion
United Kingdom / 162 (6) / 164 / 2 (0)
France / 21 (2) / 1 / 0
Republic of Ireland / 4 (1) / 2 / 0
Italy / 1 (0) / 0 / 0
USA / 3 (1*) / 2 / 0 / 0
Canada / 1 (0) / 1 / 0
Saudi Arabia / 1 (1) / 0 / 0
Japan / 1** (0) / 0 / 0
Netherlands*** / 2 (0) / 0 / 0
Portugal / 1 (1) / 0 / 0
Spain / 1 (0) / 0 / 0
Total / 197 (11) / - / 2
Footnotes
----------
* One case probably contracted in Saudi Arabia [see part (5) below],
and 2 in U.K.
** Residence in the UK for 24 days
*** Data for the Netherlands case (see part [4] below) was omitted in
error from the corresponding table for October posted on 31 Oct 2006
--
ProMED-mail
<promed@promedmail.org>
******
[3] USA - CJD National Prion Disease Surveillance Data
Date: Wed 8 Nov 2006
From: Terry S. Singeltary Sr <flounder9@verizon.net>
Source: CJD Surveillance, National Prion Disease Pathology
Surveillance Center, 8 Nov 2006 [edited]
<http://www.cjdsurveillance.com/resources-casereport.html>
Resources/Case Report
---------------------
Year / Referral / Total / Sporadic / Familial / Iatrogenic / vCJD
1997 / 104 / 60 / 54 / 6 / 0 / 0
1998 / 94 / 51 / 44 / 6 / 1 / 0
1999 / 114 / 74 / 65 / 9 / 0 / 0
2000 / 169 / 111 / 97 / 12 / 2 / 0
2001 / 2247 / 154 / 138 / 16 / 0 / 0
2002 / 265 / 151 / 127 / 22 / 1 / 0
2003 / 284 / 191 / 142 / 45 / 1 / 0
2004 / 360 / 202 / 167 / 21 / 0 / 1*
2005 / 357 / 201 / 144 / 39 / 0 / 0
2006 / 208 / 86 / 46 / 8 / 0 /1**
Total / 2202 / 1281 / 1024 / 184 / 5 / 2*
* Acquired in the United Kingdom
** Acquired in Saudi Arabia [see part (5) below]
[The gradual increase in sporadic and other forms of CJD in the USA
throughout this period may merely reflect improvements in
surveillance and diagnosis rather than a real increase in incidence.
For example, according to the tables above, there were approximately
1 per million cases of sporadic CJD in the USA during 2005, compared
with 2 cases per million in the UK during the same period. This
difference could be indicative of a real difference in incidence or a
difference in efficiency of diagnosis. - Mod.CP]
--
Terry S. Singeltary Sr
<flounder9@verizon.net>
continued.........
*******************************
A ProMED-mail post
<http://www.promedmail.org>
ProMED-mail is a program of the
International Society for Infectious Diseases
<http://www.isid.org>
[The definition of the designations deaths, definite cases, probable
vCJD cases, and the case definitions can be found by accessing the
Department of Health website, or by reference to a previous
ProMED-mail post in this thread (for example, CJD (new var.) - UK:
update March 2002 20020305.3693).
Data on vCJD cases from other parts of the world are now included in
these updates whenever available.
Also, data on other forms of CJD (sporadic, iatrogenic, familial and
GSS) are now included when they have some relevance to the incidence
and etiology of vCJD. - Mod.CP]
In this update:
[1] UK: Department of Health monthly vCJD and CJD statistics, Mon 4 Dec 2006
[2] EUROCJD data as of 31 October 2006
[3] National (US) Prion Disease Pathology Surveillance Center Data: 8 Nov 2006
[4] The Netherlands: 2nd vCJD death
[5] USA: 3rd vCJD case (ex Saudi Arabia)
******
[1] UK: vCJD and CJD statistics
Date: Mon 4 Dec 2006
From: ProMED-mail <promed@promedmail.org>
Source: UK Department of Health, Monthly Creutzfeldt-Jakob Disease
Statistics, Mon 4 Dec 2006 [edited]
<http://www.gnn.gov.uk/environment/fullDetail.asp?ReleaseID=247744&NewsAreaID=2&NavigatedFromDepartment=False>
The Department of Health is today [Mon 4 Dec 2006] issuing the latest
information about the numbers of known cases of Creutzfeldt-Jakob
disease. This includes cases of variant Creutzfeldt-Jakob disease
[abbreviated in ProMED-mail as CJD (new var.) or vCJD], the form of
the disease thought to be linked to BSE (bovine spongiform encephalopathy).
Definite and probable CJD cases in the UK, as at Fri 1 Dec 2006
----------------------------------------------------------------
Summary of vCJD cases - deaths
------------------------------
Deaths from definite vCJD (confirmed): 112
Deaths from probable vCJD (without neuropathological confirmation): 46
Deaths from probable vCJD (neuropathological confirmation pending): 0
Number of deaths from definite or probable vCJD (as above): 158
Summary of vCJD cases - alive
-----------------------------
Number of probable vCJD cases still alive: 6
Total
-----
Number of definite or probable vCJD (dead and alive): 164
(The next table will be published on Mon 8 Jan 2007).
Since the previous monthly statistics were released on Mon 6 Nov
2006, the total number of deaths from definite vCJD remains unchanged
and stands at 158. The overall total number of definite or probable
vCJD cases (dead and alive) remains unchanged at 164.
These data are consistent with the view that the vCJD outbreak in the
UK is in decline. The peak number of deaths was 28 in the year 2000,
followed by 20 in 2001, 17 in 2002, 18 in 2003, 9 in 2004, and 5 in
2005. The number of deaths due to definite or probable vCJD in the UK
during the first 11 months of 2006 remains at 5.
Totals for all types of CJD cases in the UK in 2005 and 2006
----------------------------------------------------
As of Fri 1 Dec 2006, in the UK in the year 2005, there were 123
referrals of suspected CJD, and there were 65 deaths from sporadic
CJD, 7 from familial CJD, 3 from iatrogenic CJD, 6 GSS
(Gerstmann-Straussler-Scheinker) syndrome cases, and 5 deaths from vCJD.
The corresponding figures so far for the 1st 11 months of 2006 are:
98 referrals, 53 deaths from sporadic CJD, 5 from vCJD, 5 from
familial CJD, 3 from GSS and one from iatrogenic CJD.
During the period from 1995, when vCJD was first diagnosed, up to the
present there have been 953 deaths from all forms of CJD including
the 158 deaths attributable to definite or probable vCJD.
[These data are accessible via
<http://www.gnn.gov.uk/environment/fullDetail.asp?ReleaseID=247744&NewsAreaID=2&NavigatedFromDepartment=False>]
--
ProMED-mail
<promed@promedmail.org>
******
[2] EU - EUROCJD Data
Date: Tue 31 Oct 2006
From: ProMED-mail <promed@promedmail.org>
Source: EUROCJD 31 Oct 2006 [edited]
<http://www.eurocjd.ed.ac.uk/vcjdworldeuro.htm>
The European And Allied Countries Collaborative Study Group of CJD (EUCJD)
----------------------------------------------------
This web-site includes information from 2 projects funded by the
European Commission. The EUROCJD project started in 1993 and compares
data from national registries in Australia, Austria, Canada, France,
Germany, Italy, the Netherlands, Slovakia, Spain, Switzerland and the
UK. The NEUROCJD project started in 1998 after the European Union
Council recommended that epidemiological surveillance of CJD should
be extended to all member states. The member states involved in this
project are Belgium, Denmark, Finland, Greece, Iceland, Ireland,
Israel, Norway and Portugal. Both projects are coordinated from the
U.K. National CJD Surveillance Unit based in Edinburgh.
Current data as at November 2006*
---------------------------------
Country / Total No. of Primary cases (No. alive) / Cumulative
residence in UK (>6 months) / Secondary transmission by blood transfusion
United Kingdom / 162 (6) / 164 / 2 (0)
France / 21 (2) / 1 / 0
Republic of Ireland / 4 (1) / 2 / 0
Italy / 1 (0) / 0 / 0
USA / 3 (1*) / 2 / 0 / 0
Canada / 1 (0) / 1 / 0
Saudi Arabia / 1 (1) / 0 / 0
Japan / 1** (0) / 0 / 0
Netherlands*** / 2 (0) / 0 / 0
Portugal / 1 (1) / 0 / 0
Spain / 1 (0) / 0 / 0
Total / 197 (11) / - / 2
Footnotes
----------
* One case probably contracted in Saudi Arabia [see part (5) below],
and 2 in U.K.
** Residence in the UK for 24 days
*** Data for the Netherlands case (see part [4] below) was omitted in
error from the corresponding table for October posted on 31 Oct 2006
--
ProMED-mail
<promed@promedmail.org>
******
[3] USA - CJD National Prion Disease Surveillance Data
Date: Wed 8 Nov 2006
From: Terry S. Singeltary Sr <flounder9@verizon.net>
Source: CJD Surveillance, National Prion Disease Pathology
Surveillance Center, 8 Nov 2006 [edited]
<http://www.cjdsurveillance.com/resources-casereport.html>
Resources/Case Report
---------------------
Year / Referral / Total / Sporadic / Familial / Iatrogenic / vCJD
1997 / 104 / 60 / 54 / 6 / 0 / 0
1998 / 94 / 51 / 44 / 6 / 1 / 0
1999 / 114 / 74 / 65 / 9 / 0 / 0
2000 / 169 / 111 / 97 / 12 / 2 / 0
2001 / 2247 / 154 / 138 / 16 / 0 / 0
2002 / 265 / 151 / 127 / 22 / 1 / 0
2003 / 284 / 191 / 142 / 45 / 1 / 0
2004 / 360 / 202 / 167 / 21 / 0 / 1*
2005 / 357 / 201 / 144 / 39 / 0 / 0
2006 / 208 / 86 / 46 / 8 / 0 /1**
Total / 2202 / 1281 / 1024 / 184 / 5 / 2*
* Acquired in the United Kingdom
** Acquired in Saudi Arabia [see part (5) below]
[The gradual increase in sporadic and other forms of CJD in the USA
throughout this period may merely reflect improvements in
surveillance and diagnosis rather than a real increase in incidence.
For example, according to the tables above, there were approximately
1 per million cases of sporadic CJD in the USA during 2005, compared
with 2 cases per million in the UK during the same period. This
difference could be indicative of a real difference in incidence or a
difference in efficiency of diagnosis. - Mod.CP]
--
Terry S. Singeltary Sr
<flounder9@verizon.net>
continued.........