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View Full Version : Are people with ASD's sedative resistent?


Aspigander
11-30-2008, 06:46 PM
I've always been kind of difficult to sedate, and I'm wondering if it has to do with the Asperger's.

First instance I remember -- I was having braces removed (sometime when I was a teenager -- I think 10th grade). Those who have had braces or know those who have will know about those little things they glue on the teeth to hold the wires. Well the doc was trying to remove those things from two rather fragile teeth (or rather ones that have roots that don't hold very well, and I was told that the long term prognosis for those particular teeth was not good). Anyway, worried that those teeth might pop out, I kept involuntarily jumping when the doctor went to remove them. He was able to remove the things from the teeth that were not of concern, but sent me home with these two teeth still adorned because he was afraid I'd jump at the wrong time and he wouldn't be able to pull out fast enough and I'd get hurt. He said I should get valium or something.

My mom called the psychiatrist I was seeing at the time because I was on meds and she wanted to make sure whatever was prescribed wouldn't mess with what I was on at the time. The doc prescribed valium at a dose that he told my mom would have me fall asleep for the procedure.

Not even close. I guess it phased me enough that I wasn't *as* jumpy (but still a little bit so). They were able to remove the things from the teeth. But it wasn't until after the procedure and I was leaving that I even noticed any effect. I did kind of stagger a bit.

Definitely no where near falling asleep.

Second instance -- An MRI was ordered when I was 19 to check out my pituitary gland (I won't go into detail, but you know that monthly occurrence that's supposed to happen to females starting sometime during adolescence...well it never did). They asked if I'm claustrophobic. No. They asked if I have trouble holding still. YES!! I also think I mentioned at the time that valium didn't effect me much. So they gave me 1mg of ativan. That. Did. Not. Phase. Me. At. All. Fortunately, I managed to keep still enough that the images came out clear enough.

Third, fourth, and probably fifth instance -- Because of a cyst they found near the pituitary, they wanted to check the MRI periodically. It was a different doc at this point, and again I was prescribed 1mg ativan. After several times of not being phased by ativan, I'd asked them to bump the dose an mg or two to see if that would help (as it *really* is hard to hold still even if I can ultimately manage). Well, I was told the folks doing the MRI don't appreciate it when they are sent comatose patients, so 1mg it was. Any time I've had 1mg of ativan, it. Did. Nothing.

Next instance -- new doctor. She wanted another repeat of the MRI. I pretty much told her ativan doesn't work. So she prescribed 10mg of valium. Not that my previous experience of valium suggested I was amenable to it, but it did phase me a bit and I don't think it was 10mg that time, so we'll see what 10mg does. Well, it did help and it was easier to hold still, but it seemed to wear off quickly (it was probably around a half hour or so scan, and right almost at the end the valium stopped working).

And finally, the most recent instance -- I had some issues that led to referral to a neurologist, who ordered a spinal MRI. When talking sedatives, he asked how I was with ativan, valium, and the like. I said ativan didn't phase me, valium did but not a whole lot (though enough) but not for long. So he prescribed 10mg ambien. Yep, that's right. That stuff that's supposed to have you zonked for eight hours. It effected me more than the ativan, but less the valium. Enough to make me say something kind of strange while relaying my symptoms to the tech, but not enough to really help me hold still. Basically, my thinking was slow, but that was about it.

So...I'm just wondering -- are those on the spectrum known for being resistant to sedatives?

peglem
11-30-2008, 07:31 PM
My daughter does not sedate easily. 10mg of valium makes it so she can sorta cooperate for some procedures (like a blood draw) The dentist gives her 20mg which definitely helps, but does wear off quickly. She was given quite a high dose of valium before her tonsillectomy (to make it easier to insert IV for anesthesia). The staff was amazed that it didn't put her to sleep- did make it impossible for her to walk, but she was still a struggling a bit when they took her for surgery. I'm always cautioned that she'll probably sleep for several hours after procedures, but she never does...always very alert and hyper (normal state of being) soon after sedation/anethesia.

Isabelle
12-01-2008, 01:37 AM
it was called "paradoxical reaction". your mind might be slow but your body keeps going and going like the energizer rabbit. anybody can be affected.

milivica
12-01-2008, 02:39 AM
Once I got laughing gas at the dentist, like 3 or so years ago. It was my first time, and I'd heard how 'funny' everything is when you're on it, so I was almost eager to get it. Well, all it did was make me very irritable. I asked about it here on the forum, someone told me it sounded like a reaction to having a vitamin B deficiency, that I should be sure I wasn't deficient in the B vitamins (maybe it was B12).

I don't understand how exactly sedatives work, if they make your brain produce chemicals to make you sleepy or if they bond with something in your brain to prevent chemicals that keep you awake and alert from being active. Find out exactly what the sedatives that didn't work for you do in your brain, how they work, maybe it will be helpful in uncovering something that will help you, weather autism related or not.

For me, generally things that are supposed to be a stimulant make me sleepy instead, or, don't work at all. Coffee being one of them - though caffeine isn't a stimulant, rather a suppressant...you have chemicals in your brain that get released to calm you, coffee suppresses that...so doesn't actually stimulate you but rather stops your brain from producing calming chemicals. I'm sure one person that doesn't need LESS ability to remain calm! It's neat to find out how stuff works once inside your body. Look up different sedatives, find out about the ones that didn't work for you. Valium doesn't work for me, I can't sleep at night, never could fall asleep/stay asleep so take ambien for that and wow taking only 1/4 dose has for at least a year if not two, knocked me out.

Kristen (ColeysMom)
12-01-2008, 10:22 AM
As far as sedatives go, Coley hasn't had issue with them 'working' rather the opposite, they have trouble waking him out of it, real trouble. His dad is the same way. Both of them have had to stay in the hospital over night after a day procedure because of the effects of the anethesia (is that different than a sedative?).

As for meds that make you sleepy, like benadryl and tegretol (obviously prescribed for something else, but we were told it has a calming/behavioral side effect)...ya, NOT! Both made him psycho...not just hyper, like seriously crazed, wired, no sleep, insane... periactin did the same thing and wasn't supposed to have any effect either way.

How are you with other meds?

Mili has a good suggestion...maybe figuring that out will shed some light on things...good luck!

KJ

wallyw1
12-01-2008, 10:37 AM
The various sedatives and other meds used to calm a person have always had the opposite effect on Wally.
The sedatives that did seem to work, as time went on, would take longer and longer to take hold with each use.
Wally's dad

Keggy
12-01-2008, 01:03 PM
I would try hypnosis. Try it long before you have another need for sedation. Besides being able to help you to relax hypnosis can be used as an analgesic.

Do you drink caffinated coffee? If so, does it calm you down?

edited to add:
I ask becaue if you were to drink a small amount of coffee, or some other caffiene, it may calm you down. It is based on the homeopathic concept that substances that produce symptoms will have a curative effect when given in very dilute quantities to "sick" people who exhibit those same symptoms.

Not saying you are sick... its the only way I can explain it.