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MuonOne
01-09-2008, 04:43 PM
Child Neurology, c. 2006, 7th edition
edited by John H. Menkes, Harvey B. Sarnat, Bernard L. Maria
abstract (from pages 187-188)
"In a few families, progressive degeneration of the anterior horn cells and pyramidal tracts appears before age 20 years. . . . transmission is either autosomal dominant or autosomal recessive. . . . Recessive forms of ALS usually have a juvenile onset . . . . The most prevalent form has been mapped to chromosome 2q33 and has been designated ALS2. . . . (is t)he most likely form to be encountered in the pediactric population (and can commence) as early as 3 years of age. . . . Treatment: No treatment is available."

so I ask, do persons with hereditary ALS try rilozule, and if so, is there recognizable benefits???

A table is included that shows fALS divided into five classes lables ALS1, ALS2, ALS3, ALS4 and ALS5.

not all are terminal.

MuonOne
01-22-2008, 12:32 PM
Several additional books with references to ALS that I hadn't seen . . .

Adult Neurogenesis
Gage, Kempermann, Song
copyright 2007
Cold Spring Harbor Laboratory Press

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Neurology
Mark, Mumenthaler, Heinrich, Mattle w/Ethan Taub 4th edition
copyright 2004
Thieme
p434-437

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Oxford Handbook of Neurology
Manji, Connolly, Dorward, Kitchen, Mehta, Wills
Oxford University Press
copyright 2007
p224-227

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Netter's Concise Neurology
Misulis, Head
Saunders
copyright 2007
p357,367-369,383
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The number of sealed neurology texts appears to be increasing . . . , while I thought that there were laboratory tests that show increased or elevated glutamate levels, these references indicate that 'routine' laboratory tests are normal . . . I thought that increased glutamate levels was something that could be detected in persons with ALS, are such tests not routine?

MuonOne
01-25-2008, 12:23 PM
Textbook of Neural Repair and Rehabilitation, Volume II
Selzer, Clarke, Cohen, Duncan, Gage
Cambridge University Press (United Kingdom)
copyright 2006
p276-280, 540 volume I, 198, 659-660 Volume II