annelb
10-03-2006, 08:50 PM
I posted this on the Gluten Sensitivity/Celiac Disease forum. Three years ago I started my journey here on the PN forum trying to discover something that would help my PN. It was here that I read JCC's posts about the link between gluten and IPN. I was lucky. Through Enterolab testing I discovered I was gluten sensitive. Living GF has made a tremendous difference in my PN and my life.
I understand that not everyone who has IPN is gluten sensitive but it should not be overlooked.
This article by Dr. Hadjavissiliou shows improvement of IPN in those who chose a GF diet over those who didn't. The improvement was subjective and objective. These people had circulating antibodies to gluten - no reference to biopsy. He is testing them for gluten sensitivity only.
If you want to see the other articles about gluten and neurological disease that Dr. Hadjavissiliou has contributed to, please go to http://brain.hastypastry.net/forums/showpost.php?p=845&postcount=2
Anne
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=17013890&query_hl=1&itool=pubmed_docsum
Muscle Nerve. 2006 Sep 29; [Epub ahead of print] Related Articles, Links
Dietary treatment of gluten neuropathy.
Hadjivassiliou M, Kandler RH, Chattopadhyay AK, Davies-Jones AG, Jarratt JA, Sanders DS, Sharrack B, Grunewald RA.
Department of Neurology, The Royal Hallamshire Hospital, Glossop Road, Sheffield S10 2JF, UK.
We studied the effect of a gluten-free diet in patients with idiopathic sensorimotor axonal neuropathy and circulating antigliadin antibodies. Consecutive patients underwent baseline neurophysiological assessment and were offered a gluten-free diet. Those who went on the diet formed the intention-to-treat group and those who did not were the control group. Repeat neurophysiological assessment and subjective evaluation of neuropathy symptoms were performed at 1 year. A total of 35 patients participated in the study, with 25 patients going on the diet and 10 not doing so. There was a significant difference in the change of sural sensory action potentials (pre-defined primary endpoint), with evidence of improvement in the intention-to-treat group and deterioration in the control group. Subjective change in neuropathy symptoms also showed significant differences, with patients in the intention-to-treat group reporting improvement and those in the control group reporting deterioration. Gluten-free diet may thus be a useful therapeutic intervention for patients with gluten neuropathy. Muscle Nerve, 2006.
PMID: 17013890 [PubMed - as supplied by publisher]
I understand that not everyone who has IPN is gluten sensitive but it should not be overlooked.
This article by Dr. Hadjavissiliou shows improvement of IPN in those who chose a GF diet over those who didn't. The improvement was subjective and objective. These people had circulating antibodies to gluten - no reference to biopsy. He is testing them for gluten sensitivity only.
If you want to see the other articles about gluten and neurological disease that Dr. Hadjavissiliou has contributed to, please go to http://brain.hastypastry.net/forums/showpost.php?p=845&postcount=2
Anne
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=17013890&query_hl=1&itool=pubmed_docsum
Muscle Nerve. 2006 Sep 29; [Epub ahead of print] Related Articles, Links
Dietary treatment of gluten neuropathy.
Hadjivassiliou M, Kandler RH, Chattopadhyay AK, Davies-Jones AG, Jarratt JA, Sanders DS, Sharrack B, Grunewald RA.
Department of Neurology, The Royal Hallamshire Hospital, Glossop Road, Sheffield S10 2JF, UK.
We studied the effect of a gluten-free diet in patients with idiopathic sensorimotor axonal neuropathy and circulating antigliadin antibodies. Consecutive patients underwent baseline neurophysiological assessment and were offered a gluten-free diet. Those who went on the diet formed the intention-to-treat group and those who did not were the control group. Repeat neurophysiological assessment and subjective evaluation of neuropathy symptoms were performed at 1 year. A total of 35 patients participated in the study, with 25 patients going on the diet and 10 not doing so. There was a significant difference in the change of sural sensory action potentials (pre-defined primary endpoint), with evidence of improvement in the intention-to-treat group and deterioration in the control group. Subjective change in neuropathy symptoms also showed significant differences, with patients in the intention-to-treat group reporting improvement and those in the control group reporting deterioration. Gluten-free diet may thus be a useful therapeutic intervention for patients with gluten neuropathy. Muscle Nerve, 2006.
PMID: 17013890 [PubMed - as supplied by publisher]