lady_express_44
10-15-2007, 01:06 PM
Late onset multiple sclerosis
B. Topcular, N. Sozer Topcular, M. Kurtuncu, G. Akman-Demir, M. Eraksoy (Istanbul, TR)
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Multiple sclerosis (MS) is primarily a disease of young adults with the mean age at onset 30 years. The onset is also known to occur after 50 years old even into the eight decade.
The aim of this study is to reveal clinical, demographic, magnetic resonance imaging and cerebrospinal fluid findings of the late onset of MS (LOMS) (> 50 years).
The incidence of the LOMS was 0,98% in a clinic-based MS cohort (32/3250 patients at January 2007). All the patients had clinically definite multiple sclerosis according to International Panel Diagnostic Criteria . The mean age at onset was 57 (range 50-69 years). There were 20 females and 12 males(F/M ratio: 1.6:1).
The most frequent initial manifestations were sensory-motor (n=7), transvers miyelitis(n=7), followed by brain stem(n=6), serebellar(n=6), optic neuritis (n= 5), and polysemptomatic (n=1) manifestations. The patients had relapsing-remitting (n=16), relapsing progressive (n=4) and primary progressive (n=7) course. The mean EDSS score was 4.8 (range 1.0-6.5) at 2007 with the mean 7,5 years disease duration..
Brain MRI examination was performed in all patients and the findings met the Paty's radiological criteria in 24 out of 32 patients. 15 patients had lesions on only cranial MRI whereas 10 had lesions on both cranial and spinal MRIs. Oligoclonal bands were positive in 90% of the patients in whom cerebrospinal fluid was investigated.
The differential diagnosis of MS might be difficult in patients with LOMS. They tend to have a chronic progressive course from onset similar to many degenerative disorders seen in older age such as osteoarthritic myelopathy or system degenerations which can occasionally mimic MS. Sometimes cerebrovascular disease may be important in differential diagnosis.
We concluded that clinical, MRI and CSF findings of LOMS seemed to be similar to early and adult onset MS patients except for progressive-relapsing and primary progressive course were more common in LOMS group.
http://registration.akm.ch/einsicht.php?XNABSTRACT_ID=53605&XNSPRACHE_ID=2&XNKONGRESS_ID=63&XNMASKEN_ID=900
Cherie
B. Topcular, N. Sozer Topcular, M. Kurtuncu, G. Akman-Demir, M. Eraksoy (Istanbul, TR)
--------------------------------------------------------------------------------
Multiple sclerosis (MS) is primarily a disease of young adults with the mean age at onset 30 years. The onset is also known to occur after 50 years old even into the eight decade.
The aim of this study is to reveal clinical, demographic, magnetic resonance imaging and cerebrospinal fluid findings of the late onset of MS (LOMS) (> 50 years).
The incidence of the LOMS was 0,98% in a clinic-based MS cohort (32/3250 patients at January 2007). All the patients had clinically definite multiple sclerosis according to International Panel Diagnostic Criteria . The mean age at onset was 57 (range 50-69 years). There were 20 females and 12 males(F/M ratio: 1.6:1).
The most frequent initial manifestations were sensory-motor (n=7), transvers miyelitis(n=7), followed by brain stem(n=6), serebellar(n=6), optic neuritis (n= 5), and polysemptomatic (n=1) manifestations. The patients had relapsing-remitting (n=16), relapsing progressive (n=4) and primary progressive (n=7) course. The mean EDSS score was 4.8 (range 1.0-6.5) at 2007 with the mean 7,5 years disease duration..
Brain MRI examination was performed in all patients and the findings met the Paty's radiological criteria in 24 out of 32 patients. 15 patients had lesions on only cranial MRI whereas 10 had lesions on both cranial and spinal MRIs. Oligoclonal bands were positive in 90% of the patients in whom cerebrospinal fluid was investigated.
The differential diagnosis of MS might be difficult in patients with LOMS. They tend to have a chronic progressive course from onset similar to many degenerative disorders seen in older age such as osteoarthritic myelopathy or system degenerations which can occasionally mimic MS. Sometimes cerebrovascular disease may be important in differential diagnosis.
We concluded that clinical, MRI and CSF findings of LOMS seemed to be similar to early and adult onset MS patients except for progressive-relapsing and primary progressive course were more common in LOMS group.
http://registration.akm.ch/einsicht.php?XNABSTRACT_ID=53605&XNSPRACHE_ID=2&XNKONGRESS_ID=63&XNMASKEN_ID=900
Cherie