Puzzled by Genetics

[teaandtoastgirl]

I found more information regarding HAL DQ1. Does this mean what when we get our son's report if he has DQ1 genes it will list as DQ5 or DQ6? IF so, what does the coding for a double DQ1 genes look like? Who just finished that genetics for Dummies book? Did it cover this stuff in there?

Thanks so much,
Leslie

from Wikipedia
"Note on DQ Serotype Names in Relationship with Allele Names
DQ serotypes are usually a recognition of Beta chain isoform groups For example, DQ2 = alleles that start with DQB1*02 (*0201, *0202, and *0203).

DQ2 is encoded by alleles that start with DQB1*02
DQ4 is encoded by alleles that start with DQB1*04
There are two exceptions worth noting:

DQ1 is 'split' into DQ5 and DQ6, in this case the DQB1 alleles start with
DQ5 encoded by alleles that start with DQB1*05
DQ6 encoded by alleles that start with DQB1*06
DQ3 is split into DQ7, DQ8, and DQ9, but allele retain DQB1*03.
DQ7 = DQB1*0301 (or very similar alleles)
DQ8 = DQB1*0302 (or very similar alleles)
DQ9 = DQB1*0303 (or very similar alleles)

[NancyM]

I had DQB0501 and DQB0302 so I think that means... DQ1 (subtype 5?) and DQ8.

It is bizarre! Who thought of this crazy scheme?

[teaandtoastgirl]

I had DQB0501 and DQB0302 so I think that means... DQ1 (subtype 5?) and DQ8.

It is bizarre! Who thought of this crazy scheme?


Somebody with a lot of time on their hands :D

Leslie

[Zonulin]

Hmmmmm...I just dug out my son's Enterolab gene test results, and it states that his molecular analysis is HLA-DQB1*0501, 0604, with the "serologic equivalent" of HLA-DQ1,1 (Subtypes 5,6)." And then this: "HLA gene analysis reveals that you have a copy of a gene that predisposes to gluten sensitivity (HLA-DQ1) involving the DQB1*0501 subtype." This is then referred to as HLA DQ1 because it's just too complicated to list those other subtypes! ;)

After just googling HLA-DQ1, I found several pages of listings, some connecting autoimmune illnesses with that gene type. Here is just one: http://cat.inist.fr/?aModele=afficheN&cpsidt=1895778 , which contains the following conclusion:

The finding that HLA DR16 (a DR2 subtype) is associated with susceptibility to blinding trachoma, a disease that is caused by an intracellular micro-organism, is consistent with reports of an HLA DR2 association with leprosy and tuberculosis, diseases also caused by an intracellular micro-organism. Similarly, resistance to leprosy is associated with HLA DR53 as is the case with blinding trachoma described here. It is postulated that HLA DR2 or subtypes in association with HLA DQ 1 may enable an intracellular micro-organism to enter the cell or are involved in presentation of peptides derived from intracellular micro-organisms to T lymphocytes initiating a delayed hypersensitivity or autoimmune reaction. These findings are the first report that genetic factors are of major importance in the development and protection against blinding trachoma. Does that not just reek of CELL PERMEABILITY and AUTOIMMUNE DISEASE? ZONULIN rears its ugly head again.

Karen