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flatfish
04-10-2007, 01:44 PM
Subject: Mad Cow: Is America Next?
Date: April 10, 2007 at 8:02 am PST

Mad Cow: Is America Next?
WHEAT RIDGE, CO -- (MARKET WIRE) -- April 10, 2007 -- GeneThera, Inc. (OTCBB: GTHA).

The U.S. Department of Agriculture (USDA) announced in March it was reducing its national Mad Cow testing and tracking programs by 90 percent. The USDA will reduce its cattle-testing level to 40,000 cattle per year down from an average of about 360,000 cattle. The reduced testing level will cost $8 million a year. USDA said it will focus on the "most at-risk animals" that show demonstrated signs of the disease.

The decision on whether to cut back on tests was made after experts reviewed a draft analysis of data on almost 700,000 animals screened since June 2004. During that same time span, the United States slaughtered approximately 100 million cattle.

Currently, the U.S. government tests only 1 percent of the roughly 100,000 cattle slaughtered daily while the USDA's revised plan calls for testing only 0.11 percent. Many European countries and Japan are testing all slaughtered cattle. Additionally, the agency has backed off plans for a mandatory animal-tracking system, which can help identify the source of an infection and other animals at risk, and now says the program will be voluntary.

Commenting on the news, Dr. Tony Milici Chairman & CEO of GeneThera noted, "The USDA decision to greatly reduce testing for Mad Cow Disease is a matter of great concern. Despite the USDA reassuring statements about the safety of the US beef, it is far from clear, at the present time, what is the real impact of Mad Cow Disease on the cattle population in this country. Several issues also exist about the accuracy of the technology that has been used to test for Mad Cow Disease. Present techniques may not be able to detect the presence of the disease in all infected animals especially in the early stages of infection."

USDA's inspector general has criticized the USDA's testing program, saying it could have missed the highest-risk animals. The expanded system was voluntary, so it might not have captured a representative sample of the nation's herd. "It's as though the USDA was designing a 'don't look, don't find' system," said Michael Hansen, staff scientist for Consumers Union, publisher of Consumer Reports. Consumers Union thinks 100 percent of livestock should be tested. "If you do testing of 100 percent of your animals, any ones that test positive never go into the food chain," said Michael Hansen. The agriculture secretary responded by saying that the people who are saying 100 percent testing "somehow solves the problem really are misleading you. Consumers should feel better than ever about the meat that they are buying."

However, the USDA's testing program is not random. The program is voluntary and beef processors are paid to bring in test samples. Since a diseased sample would result in serious ramifications for the slaughterhouse, there is an incentive to pick samples from healthier-looking cattle.

In a letter to the FDA, McDonald's Corporation (owner of the fast food chain) "...caution[ed] against using the 18 month enhanced surveillance as a justification to relax or impede further actions. While this surveillance indicates an epidemic is not underway, it does not clear the US cattle herd from infection." McDonald's further stated, "[c]oncerning [Mad Cow], the most effective way to insure [the highest level of safety is] to create a system that processes cattle that are not exposed to the disease. ...The exemptions in the current ban as well as in the newly proposed rule make this difficult if not impossible, as there are still legal avenues for ruminants to consume potentially contaminated ruminant protein." McDonald's further stated that according to "the FDA's own statement ... tissues which are known to have infectivity (such as distal ileum, DRGs, etc) would cumulatively amount to approximately 10% of the infectivity in an infected animal. Leaving approximately 10% of the infectious tissues in the system is not good enough. The proposed rule still allows the possibility for cattle to be exposed to Mad Cow.

Furthermore, the USDA inspector general found that government inspectors sometimes allowed cattle that couldn't walk (a potential sign of Mad Cow disease) to be slaughtered, contrary to department rules aimed at preventing Mad Cow disease. The report said that at two of 12 slaughter plants reviewed, 29 non-ambulatory cattle were slaughtered in a 10-month period. The report also stated that when field scientists recommended re-testing of a cow suspected of having Mad Cow disease last year, they were overruled by USDA officials who feared a positive finding might undermine confidence in the testing program. Auditors from the inspector general's office intervened, and the specimen was sent to England for retesting. It produced the second confirmed case of Mad Cow disease in the nation.

Which leaves the question -- is our beef really Mad Cow safe?

ABOUT GENETHERA, INC.:

GeneThera, Inc. is a molecular biotechnology company located in Wheat Ridge, CO. The Company provides genetic diagnostic solutions for the veterinary and agricultural industries with future plans to include the health-care industry. The Company's proprietary diagnostic solution is based on a genetic expression assay, GEA™. The GEA is designed for a host of individual diseases, the current priority being Mad Cow Disease, Chronic Wasting Disease, a disease affecting elk and deer in North America; E.Coli 0157:H7 and Johnne's Disease, diseases affecting cattle worldwide.

"Safe Harbor" Statement: Certain statements in this release are "forward-looking" statements as defined in the Private Securities Litigation Reform Act of 1995. Such statements are subject to numerous risks and uncertainties. Actual results may vary significantly from the results expressed or implied in such statements. Factors that could cause actual results to materially differ from forward-looking statements include, but are not limited to, the Company's ability to meet the terms and conditions required to obtain its project financing, risks and delays associated with product development, risk of market acceptance of new products, risk of technology or product obsolescence, competitive risks, reliance on development partners and the need for additional capital.




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SOURCE: GeneThera, Inc.


http://www.marketwire.com/mw/release_html_b1?release_id=236696




TSS

 

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continued

flatfish
04-10-2007, 01:45 PM
USA MAD COW STRAIN MORE VIRULENT TO HUMANS THAN UK STRAIN

18 January 2007 - Draft minutes of the SEAC 95 meeting (426 KB) held on 7
December 2006 are now available.


snip...



64. A member noted that at the recent Neuroprion meeting, a study was
presented showing that in transgenic mice BSE passaged in sheep may be more
virulent and infectious to a wider range of species than bovine derived BSE.

Other work presented suggested that BSE and bovine amyloidotic spongiform
encephalopathy (BASE) MAY BE RELATED. A mutation had been identified in the
prion protein gene in an AMERICAN BASE CASE THAT WAS SIMILAR IN NATURE TO A
MUTATION FOUND IN CASES OF SPORADIC CJD.


snip...



http://www.seac.gov.uk/minutes/95.pdf




3:30 Transmission of the Italian Atypical BSE (BASE) in Humanized Mouse

Models Qingzhong Kong, Ph.D., Assistant Professor, Pathology, Case Western Reserve
University

Bovine Amyloid Spongiform Encephalopathy (BASE) is an atypical BSE strain
discovered recently in Italy, and similar or different atypical BSE cases
were also reported in other countries. The infectivity and phenotypes of
these atypical BSE strains in humans are unknown. In collaboration with
Pierluigi Gambetti, as well as Maria Caramelli and her co-workers, we have
inoculated transgenic mice expressing human prion protein with brain
homogenates from BASE or BSE infected cattle. Our data shows that about half
of the BASE-inoculated mice became infected with an average incubation time
of about 19 months; in contrast, none of the BSE-inoculated mice appear to
be infected after more than 2 years.

***These results indicate that BASE is transmissible to humans and suggest that BASE is more virulent than
classical BSE in humans.***


6:30 Close of Day One


http://www.healthtech.com/2007/tse/day1.asp




SEE STEADY INCREASE IN SPORADIC CJD IN THE USA FROM
1997 TO 2006. SPORADIC CJD CASES TRIPLED, with phenotype
of 'UNKNOWN' strain growing. ...


http://www.cjdsurveillance.com/resources-casereport.html



There is a growing number of human CJD cases, and they were presented last
week in San Francisco by Luigi Gambatti(?) from his CJD surveillance
collection.

He estimates that it may be up to 14 or 15 persons which display selectively
SPRPSC and practically no detected RPRPSC proteins.


http://www.fda.gov/ohrms/dockets/ac/06/transcripts/1006-4240t1.htm


http://www.fda.gov/ohrms/dockets/ac/06/transcripts/2006-4240t1.pdf



4th CASE VCJD VIA BLOOD TRANSFUSION, BSE, BASE, AND SPORADIC CJD

By Terry S Singeltary

Bacliff, Texas USA Jan 24, 07


http://bloodindex.org/view_news_zone.php?id=206


PDF]Freas, William TSS SUBMISSION

File Format: PDF/Adobe Acrobat -

Page 1. J Freas, William From: Sent: To: Subject: Terry S. Singeltary

Sr. [flounder@wt.net] Monday, January 08,200l 3:03 PM freas ...



http://www.fda.gov/ohrms/dockets/ac/01/slides/3681s2_09.pdf


----- Original Message -----
From: Terry S. Singeltary Sr.
To: Terry S. Singeltary Sr. ; [log in to unmask]
Cc: [log in to unmask] ; [log in to unmask]
Sent: Thursday, November 30, 2006 1:47 PM
Subject: Re: TSE advisory committee for the meeting December 15, 2006 [TSS SUBMISSION PART II]


http://lists.ifas.ufl.edu/cgi-bin/wa.exe?A2=ind0611&L=sanet-mg&T=0&P=16159


part 1


http://bsw-uiuc.net/phpBB2/viewtopic.php?p=354&sid=971c807e383ef9e5f99ffff9da002535


THE USDA JUNE 2004 ENHANCED BSE SURVEILLANCE PROGRAM WAS TERRIBLY FLAWED ;


CDC DR. PAUL BROWN TSE EXPERT COMMENTS 2006


The U.S. Department of Agriculture was quick to assure the public earlier
this week that the third case of mad cow disease did not pose a risk to
them, but what federal officials have not acknowledged is that this latest
case indicates the deadly disease has been circulating in U.S. herds for at
least a decade.

The second case, which was detected last year in a Texas cow and which USDA
officials were reluctant to verify, was approximately 12 years old.

These two cases (the latest was detected in an Alabama cow) present a
picture of the disease having been here for 10 years or so, since it is
thought that cows usually contract the disease from contaminated feed they
consume as calves. The concern is that humans can contract a fatal,
incurable, brain-wasting illness from consuming beef products contaminated
with the mad cow pathogen.

"The fact the Texas cow showed up fairly clearly implied the existence of
other undetected cases," Dr. Paul Brown, former medical director of the
National Institutes of Health's Laboratory for Central Nervous System
Studies and an expert on mad cow-like diseases, told United Press
International. "The question was, 'How many?' and we still can't answer
that."

Brown, who is preparing a scientific paper based on the latest two mad cow
cases to estimate the maximum number of infected cows that occurred in the
United States, said he has "absolutely no confidence in USDA tests before
one year ago" because of the agency's reluctance to retest the Texas cow
that initially tested positive.

USDA officials finally retested the cow and confirmed it was infected seven
months later, but only at the insistence of the agency's inspector general.

"Everything they did on the Texas cow makes everything USDA did before 2005
suspect," Brown said. ...snip...end


http://www.upi.com/ConsumerHealthDaily/view.php?StoryID=20060315-055557-1284r


CDC - Bovine Spongiform Encephalopathy and Variant Creutzfeldt ...
Dr. Paul Brown is Senior Research Scientist in the Laboratory of Central
Nervous System ... Address for correspondence: Paul Brown, Building 36, Room
4A-05, ...


http://www.cdc.gov/ncidod/eid/vol7no1/brown.htm





PAUL BROWN COMMENT TO ME ON THIS ISSUE

Tuesday, September 12, 2006 11:10 AM


"Actually, Terry, I have been critical of the USDA handling of the mad cow issue for some years, and with Linda Detwiler and others sent lengthy detailed critiques and recommendations to both the USDA and the Canadian Food Agency."


OR, what the Honorable Phyllis Fong of the OIG found ;


Audit Report

Animal and Plant Health Inspection Service

Bovine Spongiform Encephalopathy (BSE) Surveillance Program – Phase II

and

Food Safety and Inspection Service

Controls Over BSE Sampling, Specified Risk Materials, and Advanced Meat Recovery Products - Phase III

Report No. 50601-10-KC January 2006

Finding 2 Inherent Challenges in Identifying and Testing High-Risk Cattle Still Remain


http://www.usda.gov/oig/webdocs/50601-10-KC.pdf




EXPORTATION AND IMPORTATION OF ANIMALS AND ANIMAL PRODUCTS:
BSE; MRR AND IMPORTATION OF COMMODITIES, 65758-65759 [E6-19042]



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Terry S. Singeltary Sr.
P.O. Box 42
Bacliff, Texas USA 77518