Zelnorm discontinued:

[mrsdoubtfyre]

Here is a link to the information about Zelnorm at Chronic Pain here:

http://brain.hastypastry.net/forums/showthread.php?t=12219

This is how it works on selected serotonin receptors:
Tegaserod is a 5-HT4 receptor partial agonist that binds with high affinity at human 5-HT4 receptors, whereas it has no appreciable affinity for 5-HT3 or dopamine receptors. It has moderate affinity for 5-HT1 receptors. Tegaserod, by acting as an agonist at neuronal 5-HT4 receptors, triggers the release of further neurotransmitters such as calcitonin gene-related peptide from sensory neurons. The activation of 5-HT4 receptors in the gastrointestinal tract stimulates the peristaltic reflex and intestinal secretion, as well as inhibits visceral sensitivity. In vivo studies showed that tegaserod enhanced basal motor activity and normalized impaired motility throughout the gastrointestinal tract. In addition, studies demonstrated that tegaserod moderated visceral sensitivity during colorectal distension in animals.

from http://www.rxlist.com/cgi/generic/zelnorm_cp.htm
I don't know how long this link will work at www.rxlist.com since the drug is being taken off the market. But I am including it anyway.

[annelb]

Anyone with IBS should consider the possibility that it is related to gluten sensitivity or sensitivity to other foods. I will guarentee that the gluten free diet has NO adverse side effects. There is a Gluten Sensitivity/Celiac Disease forum here on Braintalk.

http://ezinearticles.com/?Irritable-Bowel-Syndrome-May-Be-Due-To-Missed-Celiac-Disease-Or-Food-Intolerance&id=229295

http://ezinearticles.com/?Food-specific-Elimination-Diets-and-Irritable-Bowel-Syndrome:-Is-It-Time-for-U.S.-Doctors-to-Look?&id=351950

Here is the FDA advisory concerning Zelnorm: http://www.fda.gov/cder/drug/advisory/tegaserod.htm
Anne