flatfish
03-11-2007, 03:56 PM
ORIGINAL PAPER
Reference materials for the evaluation of pre-mortem variant Creutzfeldt–Jakob disease diagnostic assays
J. K. Cooper,
K. Ladhani &
P. D. Minor
CJD Resource Centre, National Institute for Biological Standards and Control, Blanche Lane, South Mimms, Potters Bar EN6 3QG, UK
Correspondence: Jillian K. Cooper, CJD Resource Centre, National Institute for Biological Standards and Control, Blanche Lane, South Mimms, Potters Bar, EN6 3QG, UK E-mail: jcooper@nibsc.ac.uk
Abstract
Background and Objectives
A standard panel of materials is needed for the evaluation of assays being developed for the diagnosis of variant Creutzfeldt–Jakob disease.
Materials and Methods
Tissues from human and animals incubating transmissible spongiform encephalopathy disease have been prepared, aliquoted and where possible characterized by in vitro methods.
Results
A standardized preparation of materials has been generated.
Conclusions
Large-scale preparations of tissues and blood fractions can be used to directly compare the sensitivities of assays using different formats.
http://www.blackwell-synergy.com/doi/abs/10.1111/j.1423-0410.2007.00904.x
TSS
Reference materials for the evaluation of pre-mortem variant Creutzfeldt–Jakob disease diagnostic assays
J. K. Cooper,
K. Ladhani &
P. D. Minor
CJD Resource Centre, National Institute for Biological Standards and Control, Blanche Lane, South Mimms, Potters Bar EN6 3QG, UK
Correspondence: Jillian K. Cooper, CJD Resource Centre, National Institute for Biological Standards and Control, Blanche Lane, South Mimms, Potters Bar, EN6 3QG, UK E-mail: jcooper@nibsc.ac.uk
Abstract
Background and Objectives
A standard panel of materials is needed for the evaluation of assays being developed for the diagnosis of variant Creutzfeldt–Jakob disease.
Materials and Methods
Tissues from human and animals incubating transmissible spongiform encephalopathy disease have been prepared, aliquoted and where possible characterized by in vitro methods.
Results
A standardized preparation of materials has been generated.
Conclusions
Large-scale preparations of tissues and blood fractions can be used to directly compare the sensitivities of assays using different formats.
http://www.blackwell-synergy.com/doi/abs/10.1111/j.1423-0410.2007.00904.x
TSS